8.06.2004

Anastomotic Leak After Colorectal Cancer Surgery Linked to Lower Survival

Anastomotic Leak After Colorectal Cancer Surgery Linked to Lower Survival

medscape.com - Aug 6 2004 15:48:12 GMT
[All Headline News - News and Headlines]

Carb-laden diet linked to breast cancer

Carb-laden diet linked to breast cancer

contracostatimes.com - Aug 6 2004 15:19:32 GMT
[All Headline News - News and Headlines]

Combination of QUADRAMET and Chemotherapy to Be Evaluated in New...

Combination of QUADRAMET and Chemotherapy to Be Evaluated in New...

The trial will evaluate the safety, tolerance and efficacy of multiple doses of QUADRAMET in combination with docetaxel in patients whose cancer has progressed after receiving hormonal therapy.
[Cancer - Topix.net]

IBM, Mayo extend partnership to find 'Holy Grail' of health care

IBM, Mayo extend partnership to find 'Holy Grail' of health care

Dr. Denis Cortese, president and CEO of the Mayo Clinic, predicted that the partnership could rapidly advance health care.
[Cancer - Topix.net]

Funding changes worry oncologists

Funding changes worry oncologists

Changes in the way Medicare pays for cancer care are putting oncology departments in central Wisconsin on edge.
[Cancer - Topix.net]

8.05.2004

Five brain cancers linked to single gene

Five brain cancers linked to single gene

Hotspots in two areas of a gene that encodes a specific signaling enzyme, or kinase, are vulnerable to a variety of mutations found in five types of brain cancers, according to a report published in the August 1 issue of the journal Cancer Research. Mutations in the gene PIK3CA occur spontaneously a...
[Science Blog]

New Trial Testing Targeted Agent for High-Risk Prostate Cancer

New Trial Testing Targeted Agent for High-Risk Prostate Cancer

medicalnewstoday.com - Aug 6 2004 4:4:35 GMT
[All Headline News - News and Headlines]

PET breakthrough could affect future standard of care for deadliest skin cancer

PET breakthrough could affect future standard of care for deadliest skin cancer

medicalnewstoday.com - Aug 6 2004 4:4:35 GMT
[All Headline News - News and Headlines]

UCSD researchers are first to demonstrate molecular link between inflammation and cancer

UCSD researchers are first to demonstrate molecular link between inflammation and cancer

medicalnewstoday.com - Aug 6 2004 4:4:35 GMT
[All Headline News - News and Headlines]

American Society for Therapeutic Radiology and Oncology, American Cancer Society Join to Promote Cancer Survivorship

American Society for Therapeutic Radiology and Oncology, American Cancer Society Join to Promote Cancer Survivorship

medicalnewstoday.com - Aug 6 2004 4:4:35 GMT
[All Headline News - News and Headlines]

3 D irradiation of brain cancer in children spares IQ, memory, other cognitive functions

3 D irradiation of brain cancer in children spares IQ, memory, other cognitive functions

medicalnewstoday.com - Aug 6 2004 4:4:35 GMT
[All Headline News - News and Headlines]

Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance.

Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance.

J Neuropathol Exp Neurol. 2004 Jul; 63(7): 700-7Aldape KD, Ballman K, Furth A, Buckner JC, Giannini C, Burger PC, Scheithauer BW, Jenkins RB, James CDThe purpose of this study was to establish an accurate and accessible immunohistochemical (IHC) method for detecting vIII Egf receptor and to assess the prognostic significance of the method as applied to the detection of vIII in malignant astrocytomas. The accuracy of the method was determined by comparing vIII immunoreactivity in formalin-fixed and paraffin-embedded tumor sections versus RT-PCR results from the analysis of RNA extracted from corresponding frozen specimens. RT-PCR revealed vIII transcript in 18 of 44 cases in this series, and IHC analysis of matched formalin-fixed and paraffin-embedded sections showed EGFRvIII reactivity in each of these 18 tumors, as well as 1 additional tumor that was negative for vIII transcript. EGFR amplification was evident in all tumors expressing vIII; none of the 15 tumors lacking amplified EGFR were positive for vIII transcript or vIII protein. IHC analysis for vill expression was next applied to a large series of anaplastic astrocytomas (AAs) and glioblastoma multiforme (GBMs) from clinical trial patients with complete follow-up and that had been previously examined by FISH for amplified EGFR. Among the GBMs, vIII detection by IHC was determined in 19 of 46 cases (41.3%) with EGFR amplification, and in only 3 of 59 tumors lacking amplified EGFR (5.1%). Among the AAs, vIII expression was observed in 3 of 14 cases with amplified EGFR (21.4%) and in 6 of 49 cases without EGFR amplification (12.2%). GBM and AA patient survival analysis as a function of vIII expression showed contrasting results, with vIII positivity having no association with survival among GBM patients (p = 0.84), but being highly associated with reduced survival among AA patients (p = 0.0016). This latter finding, though quite possibly a result of vIII's association with increasing AA patient age, suggests that vIII IHC will be useful for identifying and/or confirming the identity of malignant astrocytomas whose clinical behavior is consistent with that of GBM.


[HubMed - md anderson]

Way Found to Predict Response to Cancer Drug

Way Found to Predict Response to Cancer Drug

medicinenet.com - Aug 5 2004 12:31:14 GMT
[All Headline News - News and Headlines]

ASTRO and ACS join to promote cancer survivorship

ASTRO and ACS join to promote cancer survivorship

news-medical.net - Aug 5 2004 15:4:25 GMT
[All Headline News - News and Headlines]

Colon Cancer Merely Modulated by Chemo

Colon Cancer Merely Modulated by Chemo

medicinenet.com - Aug 5 2004 12:31:14 GMT
[All Headline News - News and Headlines]

8.04.2004

BAY 43-9006 for the Treatment of Renal Cell Carcinoma Granted Orphan Drug Designation

BAY 43-9006 for the Treatment of Renal Cell Carcinoma Granted Orphan Drug Designation

Leverkusen, Germany - Bayer Pharmaceuticals Corporation announced today that BAY 43-9006 has been granted orphan drug status for the treatment of renal cell carcinoma, by the European Commission... click link for more info.
[Medical News Today]

Protein loss plays role in acute T cell leukemia

Protein loss plays role in acute T cell leukemia

The loss of a key protein (Smad3) in a pathway that helps prevent tumors from forming is specific to one form of childhood leukemia, but not to other pediatric and adult forms of leukemia, according to a new study published in the August 5, 2004, New England Journal of Medicine*... click link for more info.
[Medical News Today]

Outcome for acute lymphoblastic leukemia linked to gene expression patterns

Outcome for acute lymphoblastic leukemia linked to gene expression patterns

Finding that specific groups of genes are associated with resistance to particular drugs are important step in identifying new targets for anti-leukemia therapies... click link for more info.
[Medical News Today]

Procedure Protects Ovaries of Cancer Patients

Procedure Protects Ovaries of Cancer Patients

abcnews.com - Aug 5 2004 1:31:45 GMT
[All Headline News - News and Headlines]

Keryx Initiates First Chemotherapy Combination Study for KRX-0401...

Keryx Initiates First Chemotherapy Combination Study for KRX-0401...

This study will evaluate the safety and tolerability of three continuous daily dosing regimes of KRX-0401 (50mg, 100mg and 150mg/day) for 14 days in combination with a fixed dose of Gemcitabine given on days 1 ...
[Cancer - Topix.net]

UConn Gets Gift For Cancer Research

UConn Gets Gift For Cancer Research

A longtime UConn benefactor and his wife have donated $10 million to the UConn Health Center in hopes of making its cancer center one of the nation's elite.
[Cancer - Topix.net]

Feed : Yahoo! News – Health
Title : Genes for Leukemia Drug Resistance Identified (HealthDay)
HealthDay - WEDNESDAY, Aug. 4 (HealthDayNews) -- Researchers have identified a set of genes that makes some children resistant to the drugs used against acute lymphoblastic leukemia (ALL), the most common childhood cancer.

Read on

Feed : EurekAlert!Cancer
Title : Molecular therapeutics advance fight against brain cancer
An estimated 41,000 new cases of primary brain tumors are expected to be diagnosed in 2004, according to the American Brain Tumor Association. To further narrow the gap between diagnosis and effective therapy, physicians at the University of Pennsylvania Health System now offer several promising approaches to brain tumor treatment, including novel imaging for oncologic neurosurgery and refined genetic testing for tumors to better target treatment.

Introgen's ADVEXIN Cancer Therapy Highlighted in CancerWise(TM)

Introgen's ADVEXIN Cancer Therapy Highlighted in CancerWise(TM)

Also included in CancerWise(TM) is a Question and Answer feature with Jack A. Roth, M.D., chairman of the Department of Thoracic and Cardiovascular Surgery at M. D. Anderson and director of the W.M. Keck Center ...
[Cancer - Topix.net]

Peregrine set for clinical trial of cancer drug

Peregrine set for clinical trial of cancer drug

Peregrine Pharmaceuticals Inc., a 23-year-old Tustin drug developer that's yet to bring its first treatment to market, has finished enrolling patients in a safety trial of an experimental cancer treatment.
[Cancer - Topix.net]

More on the NIH OA plan

More on the NIH OA plan

Publishers Visit NIH To Protest Free Access Initiative, Library Journal, August 4, 2004. A short, unsigned news story on the NIH OA plan from the House Appropriations Committee. Excerpt: "While supporters of open access hailed a proposal by the National Institutes of Health (NIH) to make all taxpayer-funded NIH research freely available within six months, more than 100 publishers yesterday visited the NIH offices to voice their strong opposition. Among their complaints: the NIH tucked the measure into an appropriations bill, which denied publishers, including society publishers, the opportunity to be heard on the issue. 'This measure caught publishers completely off-guard,' said Barbara Meredith, VP of Professional and Scholarly Publishing at the Association of American Publishers (AAP). 'This essentially mandates open access without any evidentiary hearings or studies.' The meeting was hosted by NIH Chairman Elias Zerhouni, and was the first in what is expected to be a number of hearings on the proposal, including, Meredith adds, a possible colloquy sponsored by the AAP. In response to publisher outcry, Rick Johnson, director of SPARC, in a letter sent to Zerhouni yesterday, suggested that NIH had made the right choice and that publishers appeared to 'misunderstand the proposal, which proposes open archiving, not open-access publication.' Open archiving, Johnson said, 'is not a threat to journals.' "
[Open Access News]

Study links cholesterol, cancer in big women

Study links cholesterol, cancer in big women

contracostatimes.com - Aug 4 2004 15:29:14 GMT
[All Headline News - News and Headlines]

8.03.2004

Enhancing patient care earns UH pharmacy students top honors

Enhancing patient care earns UH pharmacy students top honors

First through fourth place swept by UH in Texas pharmacy association competition



Projects addressing asthma management, community wellness, high school outreach and medication labeling earned UH College of Pharmacy students top honors in a recent Texas Pharmacy Association (TPA) competition... click link for more info.
[Medical News Today]

BioMed Central to consult funders and librarians over Open Access payment model

BioMed Central to consult funders and librarians over Open Access payment model

BioMed Central, the Open Access publisher, announced today that it is to consult with librarians and funding bodies about future mechanisms for funding Open Access publishing... click link for more info.
[Medical News Today]

Feed : EurekAlert!Cancer
Title : UC Davis cancer center ranks first in clinical trials enrollment
For the third year in a row, UC Davis Cancer Center ranked first among the 283 research institutions in the Southwest Oncology Group for the number of patients enrolled in cancer clinical trials.

Feed : EurekAlert!Cancer
Title : Adjuvant chemotherapy for colon cancer offers no survival benefit after 10 years
In 1988, a team of researchers reported that, for patients with colon cancer, postoperative chemotherapy was associated with better 5-year disease-free and overall survival than surgery alone. However, this survival benefit disappeared after 10 years, according to an update of that same clinical trial that appears in the August 4 issue of the Journal of the National Cancer Institute.

Feed : Reuters: Health
Title : Low 'Good' Cholesterol May Flag Breast Cancer Risk
NEW YORK (Reuters Health) - Among older overweight women, low levels of HDL ("good") cholesterol may signal an increased risk of breast cancer risk, research suggests.

Feed : EurekAlert!Cancer
Title : Neurosurgeons at Rush explore 'smart' drug to treat brain cancer
A phase III research study being conducted at Rush University Medical Center by neurosurgeon Dr. Richard Byrne involves the use of convection-enhanced delivery, a novel drug delivery approach, to facilitate infusion of the study drug, IL13-PE38QQR, into the brain. IL13-PE38QQR is designed to attach to specific receptors on tumor cells that are not present on normal brain cells.

Feed : Reuters: Health
Title : New Test Developed to Detect Esophageal Cancer
LONDON (Reuters) - Scientists in Britain have developed a test to detect cancer of the esophagus which could improve survival rates, they said Tuesday.

Feed : ResourceShelf
Title : Web Sites Promote Unproven Cancer Therapies–Expert
Health Research Information Credibility Source: Reuters Web Sites Promote Unproven Cancer Therapies-Expert For your "be careful what you find on the web" folder. From the article, "Internet Web sites are recommending unproven complementary medicines for cancer that could interfere with conventional treatments and be dangerous or deadly, a leading expert said on Monday. Professor Edzard Ernst analyzed 32 Web sites and found many recommended treatments not supported by scientific evidence."

Feed : Medscape Headlines
Title : Bartholin's Gland Carcinoma
A 53 YO woman with no significant medical hx presented to her gynecologist with vulvar pruritis. Physical examination revealed a firm mass in the region of the left Bartholin's gland.Applied Radiology

Feed : Medscape Headlines
Title : Temozolomide Plus Interferon Alpha–2b Helpful in Melanoma
In a randomized trial, the combination of temozolomide and interferon alpha-2b is tolerable and may show a survival advantage in stage IV metastatic melanoma.

Feed : Medscape Headlines
Title : Role of Bronchoscopic Photodynamic Therapy in Lung Cancer Management
This discussion of the current status of bronchoscopic photodynamic therapy in lung cancer is based on a critical review highlighting its indications and results.Current Opinion in Pulmonary Medicine

Feed : Medscape Headlines
Title : Donations of Texts, Journals Help Rebuild Iraq's Medical Library, Clinics
Request for help generates an overwhelming response that will broaden access to current medical and nursing literature.Medscape Medical NewsCathy Tokarski

Feed : Medscape Headlines
Title : NMP–22 for Bladder Cancer Screening and Surveillance
Is NMP-22 as good as urethrocystoscopy for detecting and diagnosing bladder cancer?Urologic Nursing

Feed :
Medscape Headlines
Title : Improved Breast Cancer Screening Access Needed
To help save the lives of an estimated 40,000 women in the United States who die from breast cancer every year, better access to breast cancer screening must be available, according to a new report

Feed :
EurekAlert!Cancer
Title : Wasting away in muscle–ville
Loss of skeletal muscle tissue, termed cachexia, occurs in over half of cancer patients and, rather than tumor burden, is the direct cause of nearly one-third of cancer deaths. In the August 2 issue of the Journal of Clinical Investigation, researchers from the Ohio State University College of Medicine show specific loss of myosin heavy chain in cachexia models. Intriguingly, myosin heavy chain loss in different models occurs through different molecular mechanisms.

Feed :
EurekAlert!Cancer
Title : Pioneering the basics for new kind of cancer vaccine
Mayo Clinic and British researchers have developed a new approach to cancer vaccines that purposely kills healthy skin cells to target the immune system against tumors. The new approach has eradicated skin cancer tumors in mice.

Feed :
EurekAlert!Cancer

Title : New technique helps scientists reveal interactions between genes and drugs
Scientists have developed a new screening technique to help them look for genes that change patients' responses to cancer drugs and other medications.

Title :
Clusters of alterations on PIK3CA gene found in brain cancers
Hotspots in two areas of a gene that encodes a specific signaling enzyme, or kinase, are vulnerable to a variety of mutations found in five types of brain cancers, according to a report published in the August 1 issue of the journal Cancer Research.

EurekAlert!Cancer

Title :
Another key for the p53 door
Researchers at the Uppsala Branch of the Ludwig Institute for Cancer Research have discovered that the transcription factor Yin Yang 1 (YY1) is a novel regulator of the p53 tumor suppressor, making YY1 a novel target for cancer therapy.

EurekAlert!Cancer

Title :
ASCO releases new technology assessment
A new technology assessment from the American Society of Clinical Oncology (ASCO) states that the use of chemotherapy sensitivity and resistance assays (CSRAs) to select chemotherapeutic agents for cancer patients should not be undertaken outside of the clinical trial setting.

via EurekAlert!Cancer

Precise cancer patient data lacking in Japan

Precise cancer patient data lacking in Japan

Collating precise data on cancer patients is essential for formulating effective anticancer measures, such as testing programs, but a National Cancer Center survey has revealed that the actual number of cancer patients nationwide was almost 30 percent higher than an earlier government estimate... click link for more info.
[Medical News Today]

MayoClinic.com receives top honors

MayoClinic.com receives top honors

http://www... click link for more info.
[Medical News Today]

8.02.2004

Adherence to guidelines improves early breast cancer survival

Adherence to guidelines improves early breast cancer survival

The first study to compare survival between women with breast cancer whose treatment was based on consensus guidelines and those whose treatment was not shows that adhering to established guidelines improves survival and reduces the risk of recurrence. The study retrospectively examined whether the ...
[Science Blog]

AHA: Get Antioxidants from Food, Not Supplements

AHA: Get Antioxidants from Food, Not Supplements

WASHINGTON (Reuters) - People hoping vitamins can protect their hearts need to eat healthy foods instead of popping pills, the American Heart Association said on Monday.
[Reuters: Health]

Cancerphobia lawsuits predominate despite disproportion to actual risk of breast cancer

Cancerphobia lawsuits predominate despite disproportion to actual risk of breast cancer

Lawsuits against radiologists and other physicians based on delays in breast cancer diagnosis and treatment have become prevalent due to misconceptions of how aggressive breast cancer can be and how effective screening mammography really is, according to a new article by Leonard Berlin, MD, of the Rush North Shore Medical Center and Rush Medical College in Chicago, IL... click link for more info.
[Medical News Today]

Two pronged attack targeting EGF receptor hinders cancer cell growth

Two pronged attack targeting EGF receptor hinders cancer cell growth

Hitting the epidermal growth factor receptor (EGFR) both high and low with a combination of drugs for targeted cancer therapy curbs cancer cell growth more effectively than using the drugs each by themselves, researchers from the University of Wisconsin-Madison reported in the August 1 issue of the journal Cancer Research... click link for more info.
[Medical News Today]

Fluorescence Spectroscopy Can Tell Brain Tumor from Normal Tissue

Fluorescence Spectroscopy Can Tell Brain Tumor from Normal Tissue

When molecules in cells are stimulated by light, they respond by becoming excited and re-emitting light of varying colors (fluorescence) that can be captured and measured by highly sensitive optical equipment... click link for more info.
[Medical News Today]

Gene therapy trial for cancer patients given go ahead UK

Gene therapy trial for cancer patients given go ahead UK

Experts on the Gene Therapy Advisory Committee (UK) have given the go ahead for a large clinical trial of a new treatment for patients with Glioma - one of the most aggressive types of brain tumours for which there is currently no cure... click link for more info.
[Medical News Today]

Apple boss undergoes surgery for rare from of pancreatic cancer, has tumor removed

Apple boss undergoes surgery for rare from of pancreatic cancer, has tumor removed

Steve Jobs, Apple CEO, has had surgery for a rare form of pancreatic cancer (islet cell neuroendocrine tumor), surgeons removed a tumor... click link for more info.
[Medical News Today]

Most complementary therapies are unproven, says UK's only professor of complementary medicine

Most complementary therapies are unproven, says UK's only professor of complementary medicine

Edzard Ernst is the UK's only professor of complementary medicine - he says that the public should not place too much faith in complementary medicine's ability to cure... click link for more info.
[Medical News Today]

NTRAC awards UK\'s first grants for drug development in 2 early phase clinical trials of cancer gene therapy

NTRAC awards UK\'s first grants for drug development in 2 early phase clinical trials of cancer gene therapy

Two trials to test new gene therapies in patients with advanced cancer can finally go ahead thanks to grants totalling £300,000 that will pay for the manufacture of the drugs needed to run the early phase trials... click link for more info.
[Medical News Today]

Herbal medicine significantly inhibited the growth of gastric tumor, pharmacological study

Herbal medicine significantly inhibited the growth of gastric tumor, pharmacological study

More than one-third of US adults use some form of alternative medicine such as herbal supplements and other therapies, showed in a nationwide survey by NIH's National Center for Complementary and Alternative Medicine published in May 2004... click link for more info.
[Medical News Today]

UK cancer study questioned

UK cancer study questioned

Semiconductor workers take issue with chosen research group's former industry ties
[News from The Scientist]

Mice cloned from cancer cell

Mice cloned from cancer cell

Nuclear transfer of a melanoma cell nucleus reveals epigenetic changes to be reprogrammable
[News from The Scientist]

8.01.2004

Secrets of the Mediterranean Diet

Secrets of the Mediterranean Diet

A recent study has once again confirmed that people who closely follow 'the Mediterranean Diet' live longer than other Europeans (1)... click link for more info.
[Medical News Today]

via shrook

Combining Radiation Modalities Increases Prostate Cancer Cure Rates

Combining Radiation Modalities Increases Prostate Cancer Cure Rates

High-risk prostate cancer patients who undergo a combination of hormonal therapy, radioactive seed implant (also called brachytherapy) and external beam radiation therapy are shown to have an increased chance of cancer cure, according to a new study published in the August 1, 2004, issue of the International Journal of Radiation Oncology*Biology*Physics, the official journal of ASTRO, the American Society for Therapeutic Radiology and Oncology... click link for more info.
[Medical News Today]

via shrook

New vaccine shows promise against skin cancer

New vaccine shows promise against skin cancer

Mayo Clinic and British researchers have developed a new approach to cancer vaccines that purposely kills healthy skin cells to target the immune system against tumors. The new approach has eradicated skin cancer tumors in mice. The approach and results challenge conventional thinking on the creatio...
[Science Blog]

via shrook

Cloning Experiment Shows Cancer Reversible - Report

Cloning Experiment Shows Cancer Reversible - Report

WASHINGTON (Reuters) - A cloning experiment may show that the body itself has the ability to reverse cancer, U.S.-based researchers said on Saturday.
[Reuters: Health]

via shrook

Birthing age and ovarian cancer risk.

Birthing age and ovarian cancer risk.

Giving birth confers on women some protection against ovarian cancer. A new study suggests that the later in life the last pregnancy happens, the better the protection.
[feedsfarm.com Search: cancer]

via shrook

FBC: More Trial Data Needed Before Endocrine Therapy Is Ready for Use in Breast Cancer Treatment

FBC: More Trial Data Needed Before Endocrine Therapy Is Ready for Use in Breast Cancer Treatment

Doctors Guide Jul 30 2004 10:07PM GMT
[feedsfarm.com Search: cancer]

via shrook

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